Liquid chromatography-mass spectrometry analysis of diethylcarbamazine in human plasma for clinical pharmacokinetic studies.
Identifieur interne : 002939 ( Main/Exploration ); précédent : 002938; suivant : 002940Liquid chromatography-mass spectrometry analysis of diethylcarbamazine in human plasma for clinical pharmacokinetic studies.
Auteurs : Mark S. Schmidt [États-Unis] ; Christopher L. King [États-Unis] ; Edward K. Thomsen [Royaume-Uni] ; Peter M. Siba [Papouasie-Nouvelle-Guinée] ; Nelly Sanuku [Papouasie-Nouvelle-Guinée] ; Lawrence Fleckenstein [États-Unis]Source :
- Journal of pharmaceutical and biomedical analysis [ 1873-264X ] ; 2014.
Descripteurs français
- KwdFr :
- MESH :
English descriptors
- KwdEn :
- Albendazole (blood), Albendazole (chemistry), Chromatography, Liquid (methods), Diethylcarbamazine (blood), Diethylcarbamazine (chemistry), Elephantiasis, Filarial (blood), Humans, Ivermectin (blood), Ivermectin (chemistry), Mass Spectrometry (methods), Plasma (chemistry), Solid Phase Extraction (methods).
- MESH :
- chemical , blood : Albendazole, Diethylcarbamazine, Ivermectin.
- chemical , chemistry : Albendazole, Diethylcarbamazine, Ivermectin.
- blood : Elephantiasis, Filarial.
- chemistry : Plasma.
- methods : Chromatography, Liquid, Mass Spectrometry, Solid Phase Extraction.
- Humans.
Abstract
A sensitive and selective liquid chromatographic method using mass spectrometric detection was developed for the determination of diethylcarbamazine (DEC) in human plasma. DEC and its stable isotope internal standard d3-DEC were extracted from 0.25mL of human plasma using solid phase extraction. Chromatography was performed using a Phenomenex Synergi 4μ Fusion-RP column (2mm×250mm) with gradient elution. The retention time was approximately 4.8min. The assay was linear from 4 to 2200ng/mL. Analysis of quality control samples at 12, 300, and 1700ng/mL (N=15) had interday coefficients of variation of 8.4%, 5.4%, and 6.2%, respectively (N=15). Interday bias results were -2.2%, 6.0%, and 0.8%, respectively. Recovery of DEC from plasma ranged from 84.2% to 90.1%. The method was successfully applied to clinical samples from patients with lymphatic filariasis from a drug-drug interaction study between DEC and albendazole and/or ivermectin.
DOI: 10.1016/j.jpba.2014.05.016
PubMed: 24975211
Affiliations:
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Schmidt</name><affiliation wicri:level="4"><nlm:affiliation>College of Pharmacy, University of Iowa, Iowa City, IA 52242, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>College of Pharmacy, University of Iowa, Iowa City, IA 52242</wicri:regionArea><placeName><region type="state">Iowa</region><settlement type="city">Iowa City</settlement></placeName><orgName type="university">Université de l'Iowa</orgName></affiliation></author><author><name sortKey="King, Christopher L" sort="King, Christopher L" uniqKey="King C" first="Christopher L" last="King">Christopher L. King</name><affiliation wicri:level="2"><nlm:affiliation>School of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>School of Medicine, Case Western Reserve University, Cleveland, OH 44106</wicri:regionArea><placeName><region type="state">Ohio</region></placeName></affiliation></author><author><name sortKey="Thomsen, Edward K" sort="Thomsen, Edward K" uniqKey="Thomsen E" first="Edward K" last="Thomsen">Edward K. Thomsen</name><affiliation wicri:level="1"><nlm:affiliation>Liverpool School of Tropical Medicine, Liverpool L3 5QA, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Liverpool School of Tropical Medicine, Liverpool L3 5QA</wicri:regionArea><wicri:noRegion>Liverpool L3 5QA</wicri:noRegion></affiliation></author><author><name sortKey="Siba, Peter M" sort="Siba, Peter M" uniqKey="Siba P" first="Peter M" last="Siba">Peter M. 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Electronic address: l-fleckenstein@uiowa.edu.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>College of Pharmacy, University of Iowa, Iowa City, IA 52242</wicri:regionArea><placeName><region type="state">Iowa</region><settlement type="city">Iowa City</settlement></placeName><orgName type="university">Université de l'Iowa</orgName></affiliation></author></analytic><series><title level="j">Journal of pharmaceutical and biomedical analysis</title><idno type="eISSN">1873-264X</idno><imprint><date when="2014" type="published">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Albendazole (blood)</term><term>Albendazole (chemistry)</term><term>Chromatography, Liquid (methods)</term><term>Diethylcarbamazine (blood)</term><term>Diethylcarbamazine (chemistry)</term><term>Elephantiasis, Filarial (blood)</term><term>Humans</term><term>Ivermectin (blood)</term><term>Ivermectin (chemistry)</term><term>Mass Spectrometry (methods)</term><term>Plasma (chemistry)</term><term>Solid Phase Extraction (methods)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Albendazole ()</term><term>Albendazole (sang)</term><term>Chromatographie en phase liquide ()</term><term>Diéthylcarbamazine ()</term><term>Diéthylcarbamazine (sang)</term><term>Extraction en phase solide ()</term><term>Filariose lymphatique (sang)</term><term>Humains</term><term>Ivermectine ()</term><term>Ivermectine (sang)</term><term>Plasma sanguin ()</term><term>Spectrométrie de masse ()</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Albendazole</term><term>Diethylcarbamazine</term><term>Ivermectin</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Albendazole</term><term>Diethylcarbamazine</term><term>Ivermectin</term></keywords><keywords scheme="MESH" qualifier="blood" xml:lang="en"><term>Elephantiasis, Filarial</term></keywords><keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Plasma</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Chromatography, Liquid</term><term>Mass Spectrometry</term><term>Solid Phase Extraction</term></keywords><keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Albendazole</term><term>Diéthylcarbamazine</term><term>Filariose lymphatique</term><term>Ivermectine</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Humans</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Albendazole</term><term>Chromatographie en phase liquide</term><term>Diéthylcarbamazine</term><term>Extraction en phase solide</term><term>Humains</term><term>Ivermectine</term><term>Plasma sanguin</term><term>Spectrométrie de masse</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">A sensitive and selective liquid chromatographic method using mass spectrometric detection was developed for the determination of diethylcarbamazine (DEC) in human plasma. DEC and its stable isotope internal standard d3-DEC were extracted from 0.25mL of human plasma using solid phase extraction. Chromatography was performed using a Phenomenex Synergi 4μ Fusion-RP column (2mm×250mm) with gradient elution. The retention time was approximately 4.8min. The assay was linear from 4 to 2200ng/mL. Analysis of quality control samples at 12, 300, and 1700ng/mL (N=15) had interday coefficients of variation of 8.4%, 5.4%, and 6.2%, respectively (N=15). Interday bias results were -2.2%, 6.0%, and 0.8%, respectively. Recovery of DEC from plasma ranged from 84.2% to 90.1%. The method was successfully applied to clinical samples from patients with lymphatic filariasis from a drug-drug interaction study between DEC and albendazole and/or ivermectin.</div></front></TEI><affiliations><list><country><li>Papouasie-Nouvelle-Guinée</li><li>Royaume-Uni</li><li>États-Unis</li></country><region><li>Iowa</li><li>Ohio</li></region><settlement><li>Iowa City</li></settlement><orgName><li>Université de l'Iowa</li></orgName></list><tree><country name="États-Unis"><region name="Iowa"><name sortKey="Schmidt, Mark S" sort="Schmidt, Mark S" uniqKey="Schmidt M" first="Mark S" last="Schmidt">Mark S. Schmidt</name></region><name sortKey="Fleckenstein, Lawrence" sort="Fleckenstein, Lawrence" uniqKey="Fleckenstein L" first="Lawrence" last="Fleckenstein">Lawrence Fleckenstein</name><name sortKey="King, Christopher L" sort="King, Christopher L" uniqKey="King C" first="Christopher L" last="King">Christopher L. King</name></country><country name="Royaume-Uni"><noRegion><name sortKey="Thomsen, Edward K" sort="Thomsen, Edward K" uniqKey="Thomsen E" first="Edward K" last="Thomsen">Edward K. Thomsen</name></noRegion></country><country name="Papouasie-Nouvelle-Guinée"><noRegion><name sortKey="Siba, Peter M" sort="Siba, Peter M" uniqKey="Siba P" first="Peter M" last="Siba">Peter M. Siba</name></noRegion><name sortKey="Sanuku, Nelly" sort="Sanuku, Nelly" uniqKey="Sanuku N" first="Nelly" last="Sanuku">Nelly Sanuku</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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